Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer
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چکیده
منابع مشابه
Dihydroorotate dehydrogenase in liver and Morris hepatomas.
Dihydroorotate dehydrogenase (DHODH) activity in the 3683, 3924A, 7288C, and 5123D Morris hepatomas was one-half that of normal rat liver. However, the DHODH activity in Morris hepatoma 7800 was the same as that of rat liver. No correlation existed between the activities of DHODH and the rates of growth of the hepatomas. The Km's of the DHODH of the hepatomas ranged from 2.5 to 11.5X IO"5 M and...
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This paper describes the first detailed study on a dihydroorotate dehydrogenase involved in pyrimidine biosynthesis. In most organisms the enzyme is membrane-bound; however, a soluble dihydroorotate dehydrogenase was produced in relatively high levels when the anaerobe, Lactobacillus bulgaricus, was released from repression. The enzyme was purified 213-fold over derepressed levels with a 39% re...
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Trypanosoma cruzi is the etiological agent of Chagas' disease, a pathogenesis that affects millions of people in Latin America. Here, we report the crystal structure of dihydroorotate dehydrogenase (DHODH) from T. cruzi strain Y solved at 2.2A resolution. DHODH is a flavin mononucleotide containing enzyme, which catalyses the oxidation of l-dihydroorotate to orotate, the fourth step and only re...
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The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline- carboxylic acid sodium salt) was shown previously to be an inhibitor of dihydroorotate dehydrogenase, the fourth enzyme of the de novo pyrimidine biosynthetic pathway. Brequinar sodium inhibits the activity of this enzyme isolated from mammalian sources only...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2020
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2020.165759